ethyl piperidine-4-carboxylate(hydrochloride), CAS No. 1126-09-6

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1126-09-6

Catalog No. EBD2199089

CAS 1126-09-6

Name ethyl piperidine-4-carboxylate(hydrochloride)

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Basic Information

Synonyms: ethylpiperidine-4-carboxylate(hydrochloride) Ethylisonipecotate Ethylpiperidine-4-carboxylate H-DL-Inp-OEt Isonipecoticacidethylester Ethyl4-piperidinecarboxylate 4-(ethoxycarbonyl)piperidinium 4-carbethoxypiperidine isonipecotinicacidethylester labotest-bblt00159543 4-piperdinecarboxylicacid,ethylester

Molecular Formula: C8H15NO2

Molecular Weight: 157.21

MDL Number: MFCD00006003

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Ethyl piperidine-4-carboxylate is an organic compound featuring a piperidine ring substituted with an ethyl ester group at the 4-position. It is a versatile heterocyclic building block, typically appearing as a colorless to pale yellow liquid. This compound serves as a crucial intermediate in pharmaceutical synthesis. Its structure, containing both a basic nitrogen atom and an ester functionality, makes it a valuable precursor for the preparation of various bioactive molecules, particularly those targeting the central nervous system. It is frequently employed in the synthesis of piperidine-based drug candidates, including analgesics, antipsychotics, and other therapeutic agents where the piperidine scaffold is a key pharmacophore. As a bifunctional synthon, it can undergo reactions at both the amine and ester groups, allowing for further derivatization. Common transformations include hydrolysis to the corresponding acid, reduction to the alcohol, or amidation, enabling the construction of diverse molecular libraries for medicinal chemistry research and development.

Physical Properties

Boiling Point: 204 °C(lit.)

Flash Point: 80 °C

Density: 1.02 g/mL at 25 °C(lit.)

Solubility: miscible

Refractivity: n20/D 1.459(lit.)

Analytical Data

Appearance: clear colorless to slightly brown liquid