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    111822-45-8

    Catalog No. EBD4022608

    CAS 111822-45-8

    Name (3aS,4S,6aR)-N-(2-aminoethyl)hexahydro-2-oxo-1H-Thieno[3,4-d]imidazole-4-pentanamide hydrochloride (1:1)

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    Basic Information

    Synonyms: (3aS,4S,6aR)-N-(2-aminoethyl)hexahydro-2-oxo-1H-Thieno[3,4-d]imidazole-4-pentanamidehydrochloride(1:1) 1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(2-aminoethyl)hexahydro-2-oxo-,hydrochloride(1:1),(3aS,4S,6aR)- 1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(2-aminoethyl)hexahydro-2-oxo-,monohydrochloride,(3aS,4S,6aR)-(9CI) 1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(2-aminoethyl)hexahydro-2-oxo-,monohydrochloride,[3aS-(3aa,4b,6aa)]- N-(2-Aminoethyl)biotinamidehydrochloride

    Molecular Formula: C12H23ClN4O2S

    Molecular Weight: 322.85

    Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Vitamins and Coenzymes Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    This compound is a key intermediate in the synthesis of biotin (vitamin B7, vitamin H) and its derivatives. It is specifically the hydrochloride salt of a biotin precursor featuring a reactive primary amine group on an ethylamino side chain. The molecule contains the characteristic fused bicyclic (tetrahydrothiophene fused with imidazolidinone) core structure of biotin, with a defined (3aS,4S,6aR) stereochemistry. Its primary application is in the research, development, and production of biotin-based pharmaceuticals, diagnostic reagents, and biochemical tools. Biotin is an essential coenzyme for carboxylase enzymes involved in fatty acid synthesis, gluconeogenesis, and amino acid metabolism. This intermediate is crucial for attaching biotin to other molecules, such as proteins, antibodies, or solid supports, to create biotinylated conjugates widely used in affinity chromatography, immunoassays (e.g., ELISA), and molecular biology techniques like pull-down assays due to the strong biotin-streptavidin interaction. As a high-purity synthetic intermediate, it is a critical material in the fine chemical and pharmaceutical industries for manufacturing biotin supplements and biotin-labeled compounds. Handling requires standard precautions for laboratory chemicals.
    Physical Properties
    mg g kg ml l t