Fmoc-L-Ser(OTrt)-OH, CAS No. 111061-56-4

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111061-56-4

Catalog No. EBD2224415

CAS 111061-56-4

Name Fmoc-L-Ser(OTrt)-OH

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Basic Information

Synonyms: N-alpha-(9-fluorenylmethyloxycarbonyl)-O-trityl-L-serine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-trityl-L-serine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-trityl-D-serine FMOC-Ser(Trt)-OH Fmoc-L-Ser(OTrt)-OH fmoc-O-trityl-L-serine

Molecular Formula: C37H31NO5

Molecular Weight: 569.65

MDL Number: MFCD00153364

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

Fmoc-O-trityl-L-serine is a protected derivative of the amino acid L-serine. Its structure features two orthogonal protecting groups: the base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group on the α-amino function and the acid-labile trityl (Trt) group on the side-chain hydroxyl group. This dual protection scheme is specifically designed for solid-phase peptide synthesis (SPPS) using the Fmoc/tBu strategy. This compound serves as a crucial building block in peptide synthesis. The trityl protection of the serine side-chain hydroxyl prevents undesired side reactions, such as O-acylation or dehydration, during the coupling cycles. It allows for the selective and controlled incorporation of serine residues into peptide chains. After chain assembly, both protecting groups can be removed under standard cleavage conditions (e.g., trifluoroacetic acid) to yield the free serine-containing peptide. It is a high-purity reagent essential for the research and development of therapeutic peptides, peptide hormones, and other biologically active peptides. Proper handling requires standard laboratory safety precautions for fine chemicals.

Physical Properties

Melting Point: 200-210 °C (dec.)

Boiling Point: 750.399 °C at 760 mmHg

Flash Point: 407.627 °C

Density: 1.257 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: white to light yellow crystal powder