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    110013-18-8

    Catalog No. EBD2215996

    CAS 110013-18-8

    Name (R)-Pyrrolidin-3-ylmethanol

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    Basic Information

    Synonyms: (R)-Pyrrolidin-3-ylmethanol (3R)-3-Pyrrolidinemethanol (R)-3-Pyrrolidinemethanol (3R)-pyrrolidin-3-ylmethanol

    Molecular Formula: C5H11NO

    Molecular Weight: 101.15

    MDL Number: MFCD09607969

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (R)-Pyrrolidin-3-ylmethanol is a chiral heterocyclic building block featuring a pyrrolidine ring substituted with a hydroxymethyl group at the 3-position. It is a versatile intermediate in organic synthesis, particularly valued for its stereogenic center and the presence of both amine and alcohol functional groups, which allow for diverse chemical modifications. Its primary and most significant application is in the pharmaceutical industry as a key chiral intermediate for the synthesis of active pharmaceutical ingredients (APIs). It serves as a crucial scaffold in the development of various drug candidates, including kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds. The (R)-enantiomer is often specifically required for its biological activity or binding affinity in these therapeutic molecules. As a bifunctional molecule, it is also employed in the synthesis of ligands for catalysis and in materials science. It is commercially available from fine chemical suppliers specializing in chiral intermediates and advanced pharmaceutical building blocks.
    Physical Properties

    Boiling Point: 176.1 °C at 760 mmHg

    Flash Point: 89.6 °C

    Density: 0.978 g/cm3

    mg g kg ml l t