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    1093070-16-6

    Catalog No. EBD1998191

    CAS 1093070-16-6

    Name 5-Amino-2-methyl-N-(1R-naphthalen-1-ylethyl)benzamide

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    Basic Information

    Synonyms: GRL 0617 GRL-0617

    Molecular Formula: C20H20N2O

    Molecular Weight: 304.39

    MDL Number: MFCD12547683

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

    Product Description:
    (R)-5-Amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide is a chiral benzamide derivative featuring a naphthalene moiety and a primary amine group. It serves as a key intermediate in the synthesis of pharmaceutical compounds. This compound is primarily utilized in the research and development of central nervous system (CNS) drugs. It acts as a crucial building block for the preparation of orexin receptor antagonists. Orexin receptors are involved in regulating sleep-wake cycles, and their antagonists are being investigated as potential treatments for insomnia and other sleep disorders. The chiral center and specific substitution pattern are essential for achieving the desired biological activity and selectivity in the final drug candidate. As a specialized intermediate, its use is confined to advanced pharmaceutical synthesis rather than general laboratory chemistry. Proper handling procedures are required due to its status as a research chemical with limited publicly available toxicological data.
    Physical Properties
    mg g kg ml l t