Boc-L-Pyroglutamic acid methyl ester, CAS No. 108963-96-8

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108963-96-8

Catalog No. EBD262443

CAS 108963-96-8

Name Boc-L-Pyroglutamic acid methyl ester

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Basic Information

Synonyms: Boc-Pyr-OMe 1,2-Pyrrolidinedicarboxylicacid,5-oxo-,1-(1,1-dimethylethyl)2-methylester,(2S)- Boc-L-Pyroglutamicacidmethylester (S)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE (S)-METHYL-N-BOC-PYROGLUTAMATE (S)-N-(tert-Butoxycarbonyl)-2-pyrrolidinone-5-carboxylicacidmethyl MethylBoc-L-Pyroglutamate 1,2-Pyrrolidinecarboxylicacid5-oxo,1-(tertButyl)-2-methylester N-tert-Butoxycarbonyl-L-pyroglutamicacidmethylester 1-tert-butyl2-methyl(2S)-5-oxopyrrolidine-1,2-dicarboxylate BOC-L-PyrOme

Molecular Formula: C11H17NO5

Molecular Weight: 243.26

MDL Number: MFCD06809720

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

Boc-L-pyroglutamic acid methyl ester is a protected derivative of L-pyroglutamic acid, featuring a Boc (tert-butoxycarbonyl) protecting group on the amine and a methyl ester on the carboxylic acid. This compound is a white to off-white crystalline powder and serves as a crucial chiral building block in organic synthesis, particularly in peptide chemistry. Its primary application is as a key intermediate in the synthesis of complex pharmaceutical compounds. The Boc-protected amine and activated ester make it a versatile precursor for constructing peptide chains and peptidomimetics. It is notably used in the research and development of various drugs, including protease inhibitors and other bioactive molecules that incorporate the pyroglutamate scaffold. The compound is valued for its stability and ease of handling in multi-step synthetic sequences. It allows for selective deprotection and further functionalization, making it a staple reagent in medicinal chemistry laboratories for the preparation of target molecules with potential therapeutic applications.

Physical Properties

Melting Point: 68-72 °C

Boiling Point: 361.6 °C at 760 mmHg

Flash Point: 172.5 °C

Density: 1.209 g/cm3

Storage: 2-8°C

Safety Information

Packing Level: III

Hazard Category: 9

Transport Codes: 3077