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    108078-14-4

    Catalog No. EBD216059

    CAS 108078-14-4

    Name 2-Iodo-3-methylbenzoic acid

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    Basic Information

    Synonyms: 2-Iodo-m-toluicacid 2-Iodo-3-methylbenzoicacid

    Molecular Formula: C8H7IO2

    Molecular Weight: 262.04

    MDL Number: MFCD00079764

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

    Product Description:
    2-Iodo-3-methylbenzoic acid is an organic compound featuring both a carboxylic acid group and an iodine atom on a methyl-substituted benzene ring. This structure makes it a versatile bifunctional building block in synthetic chemistry. Its primary application is as a key intermediate in organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling. The iodine atom serves as an excellent leaving group for palladium-catalyzed reactions, allowing for the introduction of various aryl or alkyl groups at the ortho position relative to the carboxylic acid. The carboxylic acid group can be further derivatized into esters, amides, or reduced, enabling the construction of complex molecular architectures. This compound is commonly used in pharmaceutical and agrochemical research for the synthesis of target molecules. It is typically handled as a solid and requires standard precautions for handling halogenated aromatic compounds.
    Physical Properties

    Melting Point: 150-153 °C(lit.)

    Boiling Point: 323.512 °C at 760 mmHg

    Flash Point: 149.455 °C

    Density: 1.868 g/cm3

    mg g kg ml l t