2-Amino-4-methylpyrimidine, CAS No. 108-52-1

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108-52-1

Catalog No. EBD30833

CAS 108-52-1

Name 2-Amino-4-methylpyrimidine

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Basic Information

Synonyms: 4-methylpyrimidin-2-ylamine 4-methylpyrimidin-2-amine timtec-bbsbb004343 2-amino-4-methyl-pyrimidin 2-pyrimidinamine,4-methyl- 4-methyl-2-pyrimidinamine 6-methyl-2-pyrimidinamine pyrimidine,2-amino-4-methyl- 2-amino-4-methyl-1,3-diazine 2-Amino-4-methylpyrimidine

Molecular Formula: C5H7N3

Molecular Weight: 109.13

MDL Number: MFCD00006101

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

2-Amino-4-methylpyrimidine is a heterocyclic organic compound featuring a pyrimidine ring substituted with an amino group at the 2-position and a methyl group at the 4-position. It serves as a versatile and important building block in medicinal chemistry. Its primary and most significant application is as a key intermediate in the synthesis of various pharmaceutical compounds. Notably, it is a crucial precursor in the production of sulfonamide drugs, such as sulfamerazine, an antibacterial agent. The molecule's structure allows for further functionalization, making it valuable for constructing more complex heterocyclic systems found in active pharmaceutical ingredients (APIs). Beyond its role as a pharmaceutical intermediate, 2-amino-4-methylpyrimidine is also utilized as a ligand in coordination chemistry and as a starting material in organic synthesis research. It is a solid at room temperature and should be handled with care, using appropriate personal protective equipment due to its potential irritant properties.

Physical Properties

Melting Point: 158-160 °C(lit.)

Boiling Point: 283.4 °C at 760 mmHg

Flash Point: 149.9 °C

Density: 1 g/cm3

Analytical Data

Appearance: off-white to light brown crystalline powder