3-Bromochlorobenzene, CAS No. 108-37-2

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108-37-2

Catalog No. EBD31377

CAS 108-37-2

Name 3-Bromochlorobenzene

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Basic Information

Synonyms: 1-bromo-3-chloro-benzen 1-chloro-3-bromobenzene 3-bromo-1-chlorobenzene 3-chlorobromobenzene 3-chlorophenylbromide benzene,1-bromo-3-chloro- 1-bromo-3-chlorobenzene m-bromochlorobenzene 3-Bromochlorobenzene

Molecular Formula: C6H4BrCl

Molecular Weight: 191.45

MDL Number: MFCD00000568

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates

Product Description:

1-Chloro-3-bromobenzene is an aromatic organic compound featuring both chlorine and bromine substituents on the meta positions of the benzene ring. It is a colorless to pale yellow liquid at room temperature. This compound is a versatile and valuable halogenated aromatic building block in organic synthesis. Its primary application is as a key intermediate in the synthesis of more complex molecules, particularly in the pharmaceutical and agrochemical industries. The presence of two different halogen atoms (Cl and Br) with distinct reactivity profiles allows for selective, sequential cross-coupling reactions (e.g., Suzuki, Negishi, or Buchwald-Hartwig couplings). This makes it a crucial starting material for constructing biaryl systems, which are common scaffolds in active pharmaceutical ingredients (APIs) and crop protection agents. Due to its role as a fundamental synthetic precursor, it is widely available from chemical suppliers for research and development purposes. As with many halogenated aromatics, appropriate safety precautions should be observed during handling due to potential toxicity and environmental persistence.

Physical Properties

Melting Point: -21.5 °C

Boiling Point: 196 °C(lit.)

Flash Point: 80 °C

Density: 1.63 g/mL at 25 °C(lit.)

Solubility: insoluble in water

Refractivity: n20/D 1.576(lit.)

Analytical Data

Appearance: Clear colourless to light yellow liquid