5-Methoxy-2-methylindole, CAS No. 1076-74-0

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1076-74-0

Catalog No. EBD14745

CAS 1076-74-0

Name 5-Methoxy-2-methylindole

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Basic Information

Synonyms: akosjy2082626 5-methoxy-2-methylindole,99+% 5-methoxy-2-methyindole 5-methoxy-2-methylindole,99+%25gr 5-methoxy-2-methylindole,99+%5gr 2-methyl-5-methoxyindole nsc63817 5-methoxy-2-methyl-1H-indole 5-Methoxy-2-methylindole 5-methoxy-2-methyllindole indole,5-methoxy-2-methyl-(6ci,7ci,8ci)

Molecular Formula: C10H11NO

Molecular Weight: 161.2

MDL Number: MFCD00005620

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

5-Methoxy-2-methylindole is an organic compound featuring an indole core structure substituted with a methoxy group at the 5-position and a methyl group at the 2-position. It is a solid with a molecular formula of C10H11NO and serves as a versatile heterocyclic building block. Its primary and most significant application is in pharmaceutical synthesis, where it acts as a crucial intermediate. It is notably used in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin and etodolac. The indole scaffold is a privileged structure in medicinal chemistry, and this specific derivative provides a key starting point for constructing more complex bioactive molecules. Beyond its pharmaceutical applications, 5-methoxy-2-methylindole is also employed as a synthetic intermediate in organic chemistry research and in the production of dyes and pigments due to its aromatic heterocyclic nature. It should be handled with care as it may cause skin and eye irritation.

Physical Properties

Melting Point: 86-88 °C(lit.)

Boiling Point: 145 °C / 1.5mmHg

Flash Point: 113.125 °C

Density: 1.134 g/cm3

Storage: 0-6°C

Analytical Data

Appearance: white to light beige crystalline powder