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    1073371-77-3

    Catalog No. EBD2197400

    CAS 1073371-77-3

    Name 2-Amino-5-chlorophenylboronic acid, pinacol ester

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    Basic Information

    Synonyms: 2-Amino-5-chlorophenylboronicacidpinacolester 2-Amino-5-chlorophenylboronicacid,pinacolester

    Molecular Formula: C12H17BClNO2

    Molecular Weight: 253.53

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

    Product Description:
    2-Amino-5-chlorophenylboronic acid pinacol ester is an organoboron compound featuring both an amino group and a boronic acid pinacol ester group on a chlorinated benzene ring. The pinacol ester protects the boronic acid functionality, enhancing its stability and handling properties for synthetic applications. This compound serves as a versatile building block in medicinal chemistry, particularly in the synthesis of pharmaceutical intermediates. Its primary utility lies in Suzuki-Miyaura cross-coupling reactions, where it acts as a key coupling partner to introduce the 2-amino-5-chlorophenyl moiety into more complex molecular architectures. This structural motif is valuable for constructing heterocyclic systems and bioactive molecules, including potential drug candidates targeting various therapeutic areas. As a protected boronic acid derivative, it offers improved solubility in organic solvents compared to the free acid, facilitating its use in standard organic synthesis protocols. It is a commercially available reagent used in research and development for constructing complex organic molecules.
    Physical Properties
    mg g kg ml l t