1-Bromo-3-fluorobenzene, CAS No. 1073-06-9

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1073-06-9

Catalog No. EBD16048

CAS 1073-06-9

Name 1-Bromo-3-fluorobenzene

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Basic Information

Synonyms: m-bromofluorobenzene 3-fluorobromobenzene 3-bromofluorobenzene m-fluorobromobenzene 1-bromo-3-fluoro-benzen 1-fluoro-3-bromo-benzen 1-fluoro-3-bromobenzene

Molecular Formula: C6H4BrF

Molecular Weight: 175.0

MDL Number: MFCD00000326

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

1-Bromo-3-fluorobenzene is an aromatic compound featuring both bromine and fluorine substituents on the benzene ring in a meta configuration. It is a colorless to pale yellow liquid with a molecular formula of C6H4BrF and a molecular weight of 175.00 g/mol. This compound is a versatile and valuable halogenated building block in organic synthesis. Its primary application is as a key intermediate in the synthesis of more complex molecules, particularly in the pharmaceutical and agrochemical industries. The bromine atom serves as an excellent site for cross-coupling reactions (e.g., Suzuki, Stille, Negishi couplings), while the fluorine atom can influence the electronic properties, lipophilicity, and metabolic stability of the final target compound. It is frequently used in the research and development of active pharmaceutical ingredients (APIs) and other fine chemicals. As a bifunctional aryl halide, it is a fundamental reagent in constructing biaryl systems and introducing fluorinated aromatic motifs. It is commercially available and widely used in academic and industrial research laboratories for exploring new synthetic methodologies and creating compound libraries.

Physical Properties

Melting Point: -8°C

Boiling Point: 149-151 °C(lit.)

Flash Point: 46 °C

Density: 1.567 g/mL at 25 °C(lit.)

Solubility: insoluble

Refractivity: n20/D 1.526(lit.)

Storage: Flammables area

Safety Information

Packing Level: III

Hazard Category: 3

Transport Codes: 1993C

Analytical Data

Appearance: clear colourless tolight yellow liquid