Tetrahydrothiopyran-4-one, CAS No. 1072-72-6

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1072-72-6

Catalog No. EBD38445

CAS 1072-72-6

Name Tetrahydrothiopyran-4-one

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Basic Information

Synonyms: Tetrahydro-4H-thiopyran-4-one 4-Thiacyclohexanone Tetrahydrothiopyran-4-one thian-4-one 1-thiacyclohexan-4-one 2,3,5,6-tetrahydro-4-thiopyranone 4h-tetrahydrothiopyran-4-one 4-oxotetrahydrothiopyran penthianone tetrahydro-1,4-thiapyrone tetrahydro-1-thio-4-pyrone tetrahydro-1-thio-gamma-pyrone

Molecular Formula: C5H8OS

Molecular Weight: 116.18

MDL Number: MFCD00006660

Categories: Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

Tetrahydro-4H-thiopyran-4-one is a sulfur-containing heterocyclic compound featuring a six-membered ring with a ketone group at the 4-position. It is a versatile organic building block characterized by its cyclic thioether (sulfide) and ketone functionalities. Its primary application is in organic synthesis, where it serves as a key precursor for the construction of more complex sulfur heterocycles and bioactive molecules. The ketone group is amenable to various transformations such as nucleophilic addition, reduction, and condensation reactions, while the sulfur atom can participate in oxidation or serve as a coordinating site. It is notably used in medicinal chemistry research as an intermediate for the synthesis of potential pharmaceutical agents, including those targeting the central nervous system and other therapeutic areas. This compound is a valuable synthon in the development of novel chemical entities, particularly within the realm of heterocyclic chemistry.

Physical Properties

Melting Point: 60-64 °C(lit.)

Boiling Point: 218.7 °C at 760 mmHg

Flash Point: 105.5 °C

Density: 1.134 g/cm3

Analytical Data

Appearance: White to pale yellow crystalline solid