N-Boc-D-Phenylalaninol, CAS No. 106454-69-7

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106454-69-7

Catalog No. EBD4493

CAS 106454-69-7

Name N-Boc-D-Phenylalaninol

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Basic Information

Synonyms: (R)-(+)-2-(tert-Butoxycarbonylamino)-3-phenyl-1-propanol N-Boc-D-Phenylalaninol D-(+)-BOC-PHENYLALANINOL CARBAMICACID,[(1R)-1-(HYDROXYMETHYL)-2-PHENYLETHYL]-,1,1-DIMETHYLETHYLESTER BOC-(R)-2-AMINO-3-PHENYL-1-PROPANOL BOC-D-PHENYLALANINOL BOC-D-PHE-OL N-T-BOC-D-PHENYLALANINOL N-T-BOC-D-PHENYLALANIOL tert-butyl[(1S)-1-benzyl-2-hydroxyethyl]carbamate tert-butyl[(1R)-1-benzyl-2-hydroxyethyl]carbamate CARBAMICACID,[1-(HYDROXYMETHYL)-2,2-DIPHENY

Molecular Formula: C14H21NO3

Molecular Weight: 251.32

MDL Number: MFCD00216472

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-Boc-D-phenylalaninol is a chiral amino alcohol derivative, specifically the N-Boc protected form of D-phenylalaninol. It serves as a crucial chiral building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key intermediate in the synthesis of various bioactive molecules and active pharmaceutical ingredients (APIs). The presence of both a protected amine and a hydroxyl group on a chiral backbone makes it a versatile precursor for constructing complex structures, including peptidomimetics and enzyme inhibitors. It is notably used in the synthesis of HIV protease inhibitors and other therapeutic agents where the D-phenylglycinol moiety is required. As a readily available chiral synthon, it facilitates the introduction of stereochemistry into target molecules, streamlining asymmetric synthesis routes. It is typically handled under standard laboratory conditions, with attention to its stability and storage requirements.

Physical Properties

Melting Point: 95-98 °C(lit.)

Boiling Point: 410.1 °C at 760 mmHg

Flash Point: 201.8 °C

Density: 1.085 g/cm3

Storage: 2-8°C

Analytical Data

Appearance: white to light yellow crystal powder