Nomilin, CAS No. 1063-77-0

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

1063-77-0

Catalog No. EBD52064

CAS 1063-77-0

Name Nomilin

Get Quote

Basic Information

Synonyms: 1-(Acetyloxy)-1,2-dihydroobacunoicacidepislon-lactone Nomilin fromcitrusseeds nomilin(rg) 1-(acetyloxy)-1,2-dihydroobacunoicacidε-lactone nomilin(p)(call) nomilin(p) 1-(Acetyloxy)-1,2-dihydroobacunoicacideta-lactone AI3-37935 NSC297134 Obacunoicacid,1-(acetyloxy)-1,2-dihydro-,eta-lactone (5S,5aR,5bR,7aS,8R,10aS,11aR,11bR,13aR)-8-(furan-3-yl)-1,1,5a,7a,11b-pentamethyl-3,10,12-trioxohexadecahydrooxireno[4,4a]isochromeno[6,5-g][2]benzoxepin-5-ylacetate 8-(furan-3-yl)-1,1,5a,7a,11b-pentamethyl-3,10,12-trioxohexadecahydrooxireno[4,4a]isochromeno[6,5-g][2]benzoxepin-5-ylacetate (5R,5aR,7aS,8R,10aS,11aR,11bR)-8-furan-3-yl-1,1,5a,7a,11b-pentamethyl-3,10,12-trioxohexadecahydrooxireno[4,4a]isochromeno[6,5-g][2]benzoxepin-5-ylacetate

Molecular Formula: C28H34O9

Molecular Weight: 514.56

MDL Number: MFCD00075979

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents

Product Description:

Nomilin is a triterpenoid limonoid compound primarily isolated from citrus fruits, such as grapefruit and lemon seeds. It is a secondary metabolite belonging to the class of limonoids, characterized by a furan ring and a complex, highly oxygenated structure derived from the triterpene skeleton. Extensive research has identified nomilin as a bioactive natural product with significant pharmacological potential. Its most prominent and studied application is in the field of cancer chemoprevention and therapy. Studies have demonstrated that nomilin exhibits potent anti-proliferative, pro-apoptotic, and anti-angiogenic activities against various cancer cell lines, including breast, prostate, and colon cancers. The mechanisms are multifaceted, involving the modulation of key signaling pathways such as NF-κB, MAPK, and PI3K/Akt, as well as the induction of phase II detoxifying enzymes like glutathione S-transferase. Beyond its anticancer properties, nomilin has also been investigated for its anti-inflammatory, anti-obesity, and insecticidal activities. Due to its natural origin and promising bioactivity, it serves as a valuable lead compound for drug discovery and a reference standard in phytochemical and pharmacological research.

Physical Properties

Boiling Point: 657.7 °C at 760 mmHg

Flash Point: 351.6 °C

Density: 1.33 g/cm3