cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl-N,N-diethyl-1-phenylcyclopropanecarboxamide, CAS No. 105310-75-6

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105310-75-6

Catalog No. EBD22057

CAS 105310-75-6

Name cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl-N,N-diethyl-1-phenylcyclopropanecarboxamide

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Basic Information

Synonyms: (1R,2S)-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenylcyclopropanecarboxamide 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl-N,N-diethyl-1-phenylcyclopropa (1R,2)-2-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenyl-cyclopropanecarboxamide (Z)-1-Phenyl-2-(Phthalimidomethyl)-N,N-diethyl-cyclopropanecarboxamide (1R,2R)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N,N-diethyl-1-phenylcyclopropanecarboxamide 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl-N,N-diethyl-1-phenylcyclopropanecarboxamide,cis- (Z)-1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethylcyclopropane cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl-N,N-diethyl-1-phenylcyclopropanecarboxamide (1R,2)-2-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenyl-

Molecular Formula: C23H24N2O3

Molecular Weight: 376.46

MDL Number: MFCD11111825

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

Cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenylcyclopropanecarboxamide is a synthetic organic compound featuring a cyclopropane ring substituted with a phenyl group and a carboxamide moiety, which is further extended via a methylene linker to a phthalimide (1,3-dioxoisoindoline) group. This specific cis-configured molecule is a key chiral intermediate in pharmaceutical synthesis. Its primary and well-documented application is in the synthesis of **Prasugrel**, a potent antiplatelet drug (thienopyridine P2Y12 receptor antagonist) used to prevent thrombotic events such as heart attacks and strokes in patients with acute coronary syndrome. This compound serves as a crucial precursor in the manufacturing process of Prasugrel's active metabolite. The phthalimide group acts as a protected amine, and the cyclopropane structure is integral to the drug's final active form. The synthesis and supply of this high-purity intermediate are critical for the production of the final API, Prasugrel hydrochloride. Its role is strictly as a pharmaceutical building block, and it is not typically employed as a general-purpose reagent in broader synthetic chemistry.

Physical Properties

Melting Point: 130-132 °C

Boiling Point: 546.101 °C at 760 mmHg

Flash Point: 237.521 °C

Density: 1.254 g/cm3