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    105250-17-7

    Catalog No. EBD3959

    CAS 105250-17-7

    Name (2-Aminopyridin-4-yl)methanol

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    Basic Information

    Synonyms: 2-Aminopyridine-4-methanol (2-Amino-pyridin-4-yl)-methanol 2-amino-4-(hydroxymethyl)pyridinium 2-Amino-4-pyridinemethanol (2-Aminopyridin-4-yl)methanol

    Molecular Formula: C6H8N2O

    Molecular Weight: 124.14

    MDL Number: MFCD03791261

    Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

    Product Description:
    (2-Aminopyridin-4-yl)methanol is a heterocyclic building block featuring a pyridine ring substituted with an amino group at the 2-position and a hydroxymethyl group at the 4-position. Its molecular formula is C6H8N2O, with a molecular weight of 124.14 g/mol. This compound is a key intermediate in medicinal chemistry, particularly for the synthesis of kinase inhibitors and other small-molecule drugs targeting the central nervous system or oncology pathways. The molecule serves as a versatile scaffold for constructing diverse pharmacophores. The primary amino group can undergo acylation, alkylation, or reductive amination, while the hydroxymethyl group allows for further functionalization via esterification or ether formation. It is commonly used in the development of selective kinase inhibitors, such as those targeting p38 MAP kinase or JAK family members, and in the synthesis of heterocyclic drug candidates. Additionally, it is a valuable synthetic building block for creating complex organic molecules in research settings.
    Physical Properties

    Melting Point: 80-84 °C

    Boiling Point: 329.508 °C at 760 mmHg

    Flash Point: 153.081 °C

    Density: 1.257 g/cm3

    mg g kg ml l t