Diethyl malonate, CAS No. 105-53-3

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105-53-3

Catalog No. EBD8969

CAS 105-53-3

Name Diethyl malonate

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Basic Information

Synonyms: Ethylmalonate AI3-00656 Carbethoxyaceticester Dicarbethoxymethane Diethylpropanedioate Ethylmalonate(VAN) Ethylmethanedicarboxylate Ethylpropanedioate FEMANo.2375 Malonicacid,diethylester Malonicester Methanedicarboxylicacid,diethylester NSC8864 Propanedioicacid,diethylester UNII-53A58PA183 Propanedioicacid,1,3-diethylester Diethyl1,3-propanedioate Methanedicarboxylicacid Diethylmalonate Malonicacid,diethyle

Molecular Formula: C7H12O4

Molecular Weight: 160.17

MDL Number: MFCD00009195

Categories: Functional Chemicals > Food Additives and Ingredients > Food Flavors and Fragrances

Product Description:

Diethyl malonate is a diester of malonic acid, featuring two ester groups attached to a central methylene carbon. It is a colorless liquid with a faint, pleasant odor, widely used as a fundamental building block in organic synthesis. Its primary application lies in carbon-carbon bond formation via the malonic ester synthesis, where the acidic methylene protons allow for alkylation and subsequent decarboxylation to produce substituted acetic acids. This makes it a key reagent in the synthesis of barbiturates, non-steroidal anti-inflammatory drugs (NSAIDs), and various heterocyclic compounds. In the pharmaceutical industry, it serves as an intermediate for producing active pharmaceutical ingredients (APIs) such as phenobarbital and vitamin B1. Additionally, diethyl malonate is employed in agrochemical synthesis for herbicides and insecticides, and as a flavoring agent in the food industry. It is stable under normal conditions but should be stored away from strong bases and oxidizing agents.

Physical Properties

Melting Point: −51-−50 °C(lit.)

Boiling Point: 199 °C(lit.)

Flash Point: 90 °C

Density: 5.52 (vs air)

Refractivity: n20/D 1.413(lit.)

Analytical Data

Appearance: colourless liquid