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    104632-27-1

    Catalog No. EBD2866650

    CAS 104632-27-1

    Name (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride

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    Basic Information

    Synonyms: (6R)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzo[d]thiazolediamine2HCl Dexpramipexole dihydrochloride

    Molecular Formula: C10H19Cl2N3S

    Molecular Weight: 284.25

    Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    (R)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride is a chiral, heterocyclic amine derivative. It is a key intermediate in the synthesis of Pramipexole, a non-ergoline dopamine agonist. The compound features a tetrahydrobenzothiazole core structure with a propylamino substituent at the 6-position, and its stereochemistry is defined as the (R)-enantiomer, which is crucial for its biological activity. This compound is primarily used in the pharmaceutical industry for the production of Pramipexole dihydrochloride, an important active pharmaceutical ingredient (API). Pramipexole is a potent dopamine D2 receptor agonist used for the treatment of Parkinson's disease and restless legs syndrome (RLS). The synthesis of the (R)-enantiomer is critical, as it is the therapeutically active form of the drug. Therefore, this intermediate is a vital building block in the manufacturing process of this neurological medication. As a high-purity chemical intermediate, its production and quality control are subject to stringent pharmaceutical standards to ensure the safety and efficacy of the final drug product. Its role is specific to the synthesis pathway of a well-established neurological drug, distinguishing it from general-purpose synthetic building blocks.
    Physical Properties

    Color: white to beige

    Storage: −20°C

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