2'-Amino-2'-deoxyadenosine, CAS No. 10414-81-0

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10414-81-0

Catalog No. EBD42412

CAS 10414-81-0

Name 2'-Amino-2'-deoxyadenosine

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Basic Information

Synonyms: 2'-AMINO-D-ADENOSINE 2'-Amino-2'-deoxy-D-adenosine (2R,3S,4R,5R)-4-Amino-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol 9-(2-amino-2-deoxypentofuranosyl)-9H-purin-6-amine 2'-Amino-2'-deoxyadenosine 9-(2-amino-2-deoxy-β-d-ribofuranosyl)-adenine adenosine,2'-amino,-2'-deoxy jci-2172 nsc324326

Molecular Formula: C10H14N6O3

Molecular Weight: 266.26

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2'-Amino-2'-deoxyadenosine is a modified nucleoside analog where the 2'-hydroxyl group of the ribose sugar in adenosine is replaced by an amino group. This structural modification imparts unique biochemical properties, distinguishing it from its natural counterpart. This compound serves as a crucial building block in nucleic acid chemistry and medicinal chemistry research. Its primary application lies in the synthesis of oligonucleotides with modified backbones, which are used to study RNA structure, function, and stability. It is also investigated as a potential precursor for the development of antiviral and anticancer agents, leveraging its ability to be incorporated into nucleic acids and interfere with replication or translation processes. As a specialty biochemical, it is a valuable reagent for probing enzyme mechanisms, particularly those of nucleoside kinases and polymerases, and for creating stable, nuclease-resistant oligonucleotide analogs for diagnostic and therapeutic applications.

Physical Properties

Boiling Point: 657.6 °C at 760 mmHg

Flash Point: 351.5 °C

Density: 2.08 g/cm3