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    1035270-39-3

    Catalog No. EBD582368

    CAS 1035270-39-3

    Name N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide

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    Basic Information

    Synonyms: AZD-4547 N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide AZD4547

    Molecular Formula: C26H33N5O3

    Molecular Weight: 463.57

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Targeted Protein Degradation Tools > Ligand-Linker Conjugates

    Product Description:
    N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide is a complex heterocyclic compound featuring a pyrazole core linked to a dimethylpiperazine-substituted benzamide via an amide bond. The structure incorporates a 3,5-dimethoxyphenethyl side chain, contributing to its overall lipophilicity and potential for target engagement. This compound is primarily documented as a key intermediate in medicinal chemistry research, specifically in the development of targeted protein degraders such as Proteolysis-Targeting Chimeras (PROTACs). Its structure contains elements that can serve as a ligand for E3 ubiquitin ligases (via the (3S,5R)-3,5-dimethylpiperazine moiety, a known component for binding to VHL E3 ligase) and a linker-attachment point (the pyrazole nitrogen), making it a valuable building block for constructing PROTAC molecules aimed at degrading disease-relevant proteins. As a research-grade chemical, it is not used directly as an API. Its applications are confined to preclinical drug discovery, where it is utilized to synthesize and optimize novel bifunctional degraders for evaluating their efficacy and selectivity against various therapeutic targets.
    Physical Properties
    mg g kg ml l t