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    1035235-29-0

    Catalog No. EBD2215077

    CAS 1035235-29-0

    Name 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

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    Basic Information

    Synonyms: 4-Cyano-2-fluorophenylboronicacidpinacolester 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

    Molecular Formula: C13H15BFNO2

    Molecular Weight: 247.07

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is an organic compound featuring a benzonitrile core substituted with a fluorine atom and a pinacol boronate ester group. This structure classifies it as a protected form of a boronic acid derivative, specifically the pinacol ester of (3-fluoro-4-cyanophenyl)boronic acid. Its primary application is as a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. The boronate ester group serves as a key handle for forming carbon-carbon bonds with aryl or vinyl halides, facilitated by palladium catalysts. The presence of both the electron-withdrawing cyano group and the fluorine atom on the aromatic ring makes it a valuable intermediate for constructing more complex molecules, especially in medicinal chemistry for the synthesis of potential drug candidates and pharmaceutical intermediates. This compound is typically used in research and development settings. It is sensitive to protic solvents and strong acids/bases, which can hydrolyze the boronate ester. Proper handling under inert atmosphere (e.g., nitrogen or argon) is recommended for storage and use to maintain its reactivity.
    Physical Properties
    mg g kg ml l t