methyl 3-oxo-4-aza-5±-androst-1-ene-172-carboxylate, CAS No. 103335-41-7

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103335-41-7

Catalog No. EBD233902

CAS 103335-41-7

Name methyl 3-oxo-4-aza-5±-androst-1-ene-172-carboxylate

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Basic Information

Synonyms: methyl3-oxo-4-aza-5±-androst-1-ene-172-carboxylate 172-(methoxycarbonyl)-4-aza-5±-androst-1-en-3-one Methyl3-oxo-4-azaandrost-1-ene-172-carboxylate 172-(methoxycarbonyl)-4-aza-5±-androst-1-ene-3-one Methyl3-oxo-4-aza-5a-androst-1-ene-172-carboxylate METHYL4-AZA-5ALPHA-ANDROSTA-1-EN-3-ONE-17BETA-CARBOXYLATE METHYL3-OXO-4-AZA-5-ALPHA-ANDROST-1-ENE-17-BETA-CARBOXYLATE methyl(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylate

Molecular Formula: C20H29NO3

Molecular Weight: 331.45

Categories: Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards Medicinal Chemistry > APIs and Their Salts > Urinary System Drugs

Product Description:

Methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate is a steroidal compound structurally related to dutasteride. It is specifically identified as a known impurity or a potential degradation product of dutasteride, a synthetic 4-azasteroid compound. Dutasteride is a dual inhibitor of both type I and type II 5α-reductase enzymes, used primarily in the treatment of benign prostatic hyperplasia (BPH). As a process-related impurity or a metabolite, this compound is critical in the pharmaceutical quality control of dutasteride. It is used as a reference standard (impurity standard) in analytical methods such as HPLC to monitor and control the purity of the active pharmaceutical ingredient (API) during manufacturing and in the final drug product. Its characterization and quantification are essential for ensuring drug safety, efficacy, and regulatory compliance. The presence and levels of such impurities are strictly governed by guidelines from regulatory authorities like the ICH. Therefore, this chemical serves a vital role in the pharmaceutical industry as a certified reference material for analytical testing, supporting the development and quality assurance of dutasteride-based medications.

Physical Properties

Melting Point: 280-282 °C (dec.)

Boiling Point: 478.615 °C at 760 mmHg

Flash Point: 243.258 °C

Density: 1.114 g/cm3

Analytical Data

Appearance: Off-White Solid