N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID, CAS No. 102507-13-1

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102507-13-1

Catalog No. EBD48208

CAS 102507-13-1

Name N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

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Basic Information

Synonyms: N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOICACID (S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,3-DIMETHYL-SERINE (S)-2-BOC-AMINO-3-HYDROXY-3-METHYLBUTYRICACID BOC-S-SER(3,3ME2)-OH BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOICACID BOC-L-SER(3,3-DIMETHYL) (S)-2-N-BOC-AMINO-3-HYDROXY-3-METHYLBUTYRICACID N-(tert-butoxycarbonyl)-3-hydroxy-L-valine (S)-2-tert-Butoxycarbonylamino-3-hydroxy-3-methyl-butyricacid N-(tert-butoxycarbonyl)-3-hydroxyvaline valine,N-[(1,1-dimethylethoxy)carbonyl]-3-hydroxy- N-Boc-2-amino-3-hydroxy-3-methylbutanoicacid

Molecular Formula: C10H19NO5

Molecular Weight: 233.26

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

N-Boc-3-hydroxy-L-valine is a chiral, non-proteinogenic amino acid derivative. Its chemical structure features a tert-butoxycarbonyl (Boc) protecting group on the amine functionality and a hydroxyl group on the β-carbon of the valine backbone, making it a β-hydroxy amino acid. This compound is a white to off-white crystalline powder. This Boc-protected amino acid serves as a crucial chiral building block in the synthesis of complex bioactive molecules. Its primary application is in the field of peptide and peptidomimetic chemistry, particularly for the preparation of pharmaceutical intermediates. The presence of the β-hydroxy group introduces additional functionality and stereochemical complexity, which is valuable for modulating the biological activity, solubility, and metabolic stability of target compounds. It is frequently employed in solid-phase peptide synthesis (SPPS) and medicinal chemistry research for developing new therapeutic agents. As a specialty amino acid derivative, it is not a commodity chemical but a high-value intermediate for research and development. Proper handling requires standard laboratory safety precautions, including the use of personal protective equipment, as it may cause irritation to the skin, eyes, and respiratory system.

Physical Properties

Boiling Point: 391.1 ºC at 760 mmHg

Flash Point: 190.3 ºC

Density: 1.175 g/cm3