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    101376-25-4

    Catalog No. EBD6499

    CAS 101376-25-4

    Name 3(S)-Hydroxymethyl-4-benzylmorpholine

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    Basic Information

    Synonyms: 3(S)-HYDROXYMETHYL-4-BENZYLMORPHOLINE (S)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE [(3S)-4-benzylmorpholin-3-yl]methanol

    Molecular Formula: C12H17NO2

    Molecular Weight: 207.27

    MDL Number: MFCD06799482

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (S)-4-Benzylmorpholine-3-methanol is a chiral morpholine derivative characterized by a hydroxymethyl group at the 3-position and a benzyl group at the 4-position of the morpholine ring. Its specific (S)-configuration makes it a valuable chiral building block in organic synthesis. This compound is primarily utilized as a key chiral intermediate in the pharmaceutical industry. Its core structure serves as a crucial scaffold for the synthesis of various bioactive molecules and active pharmaceutical ingredients (APIs). The presence of both a basic nitrogen atom (in the morpholine ring) and a hydroxymethyl group provides versatile handles for further chemical modifications, enabling its incorporation into more complex drug candidates. As a chiral synthon, it is particularly relevant in the development of compounds targeting the central nervous system and other therapeutic areas where stereochemistry is critical for biological activity. It is commercially available from suppliers specializing in fine chemicals and advanced pharmaceutical intermediates.
    Physical Properties

    Boiling Point: 322.7 °C at 760 mmHg

    Flash Point: 149 °C

    Density: 1.117 g/cm3

    mg g kg ml l t