Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    100927-10-4

    Catalog No. EBD52173

    CAS 100927-10-4

    Name R-2-N-BOC-propane-1,2-diamine

    Get Quote
    Basic Information

    Synonyms: R-2-N-BOC-propane-1,2-diamine Carbamicacid,[(1R)-2-amino-1-methylethyl]-,1,1-dimethylethylester (R)-2-(BOC-AMINO)-PROPANAMINE

    Molecular Formula: C8H18N2O2

    Molecular Weight: 174.24

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    N-[(1R)-2-Amino-1-methylethyl]carbamic acid tert-butyl ester is a chiral amine derivative, specifically a Boc-protected (1R)-1,2-diaminopropane. Its molecular structure features a tert-butoxycarbonyl (Boc) protecting group on the primary amine of a chiral 1,2-diaminopropane scaffold, with the stereocenter at the C1 position in the (R)-configuration. This compound is a crucial chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the production of various active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and cardiovascular diseases. The presence of both a protected primary amine and a secondary amine makes it a versatile precursor for constructing complex molecules with specific stereochemistry, which is essential for drug efficacy and safety. As a Boc-protected diamine, it is widely used in peptide coupling reactions and the synthesis of chiral ligands or catalysts. The Boc group can be readily removed under mild acidic conditions to reveal the free primary amine for further functionalization. Its high chiral purity makes it valuable for research and development in asymmetric synthesis.
    Physical Properties

    Storage: −20°C

    mg g kg ml l t