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    1006376-62-0

    Catalog No. EBD2045566

    CAS 1006376-62-0

    Name (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxamide

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    Basic Information

    Synonyms: (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxamide (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxamide

    Molecular Formula: C10H9F2NO

    Molecular Weight: 197.18

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

    Product Description:
    (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide is a chiral cyclopropane derivative. It is a key intermediate in the synthesis of approved pharmaceutical agents, most notably the antidepressant drug Levomilnacipran (Fetzima®). The compound features a trans-configured cyclopropane ring substituted with a 3,4-difluorophenyl group and a primary amide functionality. Its primary and most significant application is as a high-value chiral building block for the production of Levomilnacipran, a serotonin-norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depressive disorder. The (1R,2R) stereochemistry of this intermediate is crucial for conferring the desired biological activity of the final drug molecule. Its synthesis and supply are therefore directly tied to the pharmaceutical manufacturing process of this specific API. As a specialized chiral synthon with a defined and critical role in a commercial drug synthesis pathway, it is categorized as a pharmaceutical intermediate. It is not a commodity chemical or a general-purpose building block for broad synthetic chemistry.
    Physical Properties

    Storage: −20°C

    mg g kg ml l t