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    100276-37-7

    Catalog No. EBD4048978

    CAS 100276-37-7

    Name 6,8-Difluor-1-(methylamino)-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeure

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    Basic Information

    Molecular Formula: C16H18F2N4O3

    Molecular Weight: 352.341

    Categories: Medicinal Chemistry > APIs and Their Salts > Anti-infectives Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

    Product Description:
    6,8-Difluoro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is a key synthetic intermediate in the production of the broad-spectrum fluoroquinolone antibiotic **gatifloxacin**. Its structure features a core 3-quinolinecarboxylic acid scaffold substituted with fluorine atoms at positions 6 and 8, a methylamino group at N-1, and a 4-methylpiperazinyl moiety at position 7, which are characteristic and pharmacologically essential modifications for third-generation fluoroquinolones. This compound is specifically designed and utilized as a **penultimate intermediate** in the chemical synthesis of gatifloxacin. The presence of the 4-methylpiperazine ring is crucial for enhancing the drug's potency against Gram-positive bacteria and improving its pharmacokinetic profile. Its primary and definitive industrial application is within the pharmaceutical manufacturing sector for antibiotic production. As a highly functionalized and specific building block, its use is almost exclusively confined to the synthesis pathway of gatifloxacin. It is not considered a general-purpose synthetic reagent or a common organic synthesis building block for other applications. Handling requires standard laboratory precautions for fine chemicals.
    Physical Properties
    mg g kg ml l t