Solketal, CAS No. 100-79-8

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100-79-8

Catalog No. EBD30637

CAS 100-79-8

Name Solketal

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Basic Information

Synonyms: (+/-)-1,2-O-Isopropylideneglycerol Acetoneketalofglycerine DL-alpha,beta-Isopropylideneglycerol 2,2-dimethyl-1,3-dioxolan-4-ylmethanol glycerol1,2-isopropylideneether 4-hydroxymethyl-2,2-dimethyl-1,3-dioxolan 1,2-Isopropylidene-rac-glycerol (+,-)-2,2-Dimethyl-4-hydroxymethyl-1,3-dioxolane (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol 1,2-dioxolane [(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol 2,2-Dimethyl-1,3-dioxolane-4-methanol (+/-)-2,2-Dimethyl-1,3-dioxolane-4-metha

Molecular Formula: C6H12O3

Molecular Weight: 132.16

MDL Number: MFCD00063238

Categories: Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers Materials Chemistry > Polymers and Macromolecular Materials > Polyester and Bio-based Polymer Precursors Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks

Product Description:

Solketal, also known as 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, is a cyclic acetal derived from glycerol and acetone. It is a colorless liquid with a mild odor, serving as a protected form of glycerol where the 1,2-diol is masked as an isopropylidene ketal. Its primary application is as a versatile solvent and co-solvent in pharmaceutical and cosmetic formulations, valued for its low toxicity, biodegradability, and ability to dissolve both polar and non-polar compounds. In organic synthesis, Solketal is a key building block for producing mono- and di-glycerides, glycidyl ethers, and various chiral intermediates, as it provides a convenient handle for selective functionalization at the primary hydroxyl group while protecting the diol. It is also used as a fuel additive to reduce particulate emissions and improve cold flow properties.

Physical Properties

Boiling Point: 188-189 °C(lit.)

Flash Point: 90 °C

Density: 1.063 g/mL at 25 °C(lit.)

Solubility: miscible

Refractivity: n20/D 1.434(lit.)

Storage: 2-8°C

Analytical Data

Appearance: clear colourless liquid